While animal models remain essential in studying systemic infectious processes, immune responses, and evaluating therapies, refinement measures to reduce stress and improve welfare in experimental animals are underexplored. In this 3RTG, we will address the central hypothesis of these infections causing general stress responses and behavioural changes, which can be assessed on metabolic level or by video observation and artificial intelligence analysis, respectively. New insights into these stress responses and behavioural changes will increase our knowledge of the respective diseases whilst contributing to minimise the disease burden on the experimental animals. Our strategy will allow us to compare stress responses and behavioural data between different species and classes of pathogens, leading to important synergies by using standardised methods.

The 3RTG aims to provide scientific and educational training for doctoral candidates in infectious disease research, with a focus on host/pathogen models across various animal species. Through interdisciplinary collaboration, advanced analytical methods, and behaviour analysis, the programme seeks to improve disease models and develop new refinement approaches to enhance animal welfare.

Key points:

• Focus on stress responses and behavioural changes in infection models
• Interdisciplinary team of doctoral researchers working collaboratively
• Strong emphasis on 3R principles, animal welfare, and ethical training
• Hosted by Dahlem Research School (FUB) under the Biomedical Sciences section
• Integrated into the Berlin University Alliance, offering extensive support and training
• Prepares a new generation of scientists committed to both research excellence and animal welfare

The RTG is a member of the structured doctoral program “Biomedical Sciences” (Freie Universität Berlin).